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Traumatic Brain Injury (TBI) is a pervasive public health concern, with implications that extend beyond the realm of physical injury. This article delves into the intricate interplay between TBI and behavioral neuroscience, shedding light on the complex mechanisms that underlie the behavioral changes experienced by individuals following brain injury. TBI, resulting from external mechanical forces, disrupts the delicate balance of the brain’s structure and function, leading to a spectrum of behavioral alterations encompassing cognition, emotion, personality, and social interactions. Neurobiological mechanisms, including axonal injury, neurotransmitter imbalances, and inflammation, contribute to these changes. The brain’s remarkable neuroplasticity is harnessed for post-TBI recovery through rehabilitation strategies. Diagnosis and treatment of TBI-related behavioral changes pose unique challenges, demanding multidisciplinary approaches. Future prospects, including advanced neuroimaging techniques and targeted pharmacological interventions, offer promise for improved understanding and management of TBI-induced behavioral alterations. As the field of behavioral neuroscience advances, so does the potential to enhance the lives of those affected by TBI.